ROS1 (gen)
(Preusmjereno sa stranice C-ros-1)
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Proto-onkogenska tirozinska proteinska kinaza ROS je enzim koji je kod ljudi kodiran ROS1 genom.[1][2]
| ROS proto-onkogen 1, receptorska tirozinska kinaza | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dostupne strukture | |||||||||||
| 3ZBF | |||||||||||
| Identifikatori | |||||||||||
| Simboli | ROS1; MCF3; ROS; c-ros-1 | ||||||||||
| Vanjski ID | OMIM: 165020 MGI: 97999 HomoloGene: 2207 GeneCards: ROS1 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6098 | 19886 | |||||||||
| Ensembl | ENSG00000047936 | ENSMUSG00000019893 | |||||||||
| UniProt | P08922 | Q78DX7 | |||||||||
| Ref. Sekv. (iRNK) | NM_002944 | NM_011282 | |||||||||
| Ref. Sekv. (protein) | NP_002935 | NP_035412 | |||||||||
| Lokacija (UCSC) | Chr 6: 117.61 - 117.75 Mb | Chr 10: 52.05 - 52.2 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj proto-onkogen, koji je visoko izražen u ćelijama tumora, pripada sevenless podfamiliji tirozinskih kinaza insulinskih receptorskih gena. Protein kodiran ovim genom je tip I integralnog membranskog proteina sa tirozinskom kinaznom aktivnošću. Ovaj protein može da deluje kao receptor faktora rasta ili diferencijacije.[2]
Interakcije
urediROS1 (gen) formira interakcije sa PTPN6.[3]
Reference
uredi- ↑ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). „Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23”. Cytogenet Cell Genet 60 (2): 114–6. DOI:10.1159/000133316. PMID 1611909.
- ↑ 2,0 2,1 „Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)”.
- ↑ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). „Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1”. J. Cell Biol. (United States) 152 (2): 325–34. DOI:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449.
Literatura
uredi- Birchmeier C, O'Neill K, Riggs M, Wigler M (1990). „Characterization of ROS1 cDNA from a human glioblastoma cell line”. Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4799–803. DOI:10.1073/pnas.87.12.4799. PMC 54205. PMID 2352949.
- Sharma S, Birchmeier C, Nikawa J i dr.. (1990). „Characterization of the ros1-gene products expressed in human glioblastoma cell lines”. Oncogene Res. 5 (2): 91–100. PMID 2691958.
- Birchmeier C, Sharma S, Wigler M (1988). „Expression and rearrangement of the ROS1 gene in human glioblastoma cells”. Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9270–4. DOI:10.1073/pnas.84.24.9270. PMC 299735. PMID 2827175.
- Matsushime H, Wang LH, Shibuya M (1987). „Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule”. Mol. Cell. Biol. 6 (8): 3000–4. PMC 367872. PMID 3023956.
- Satoh H, Yoshida MC, Matsushime H i dr.. (1987). „Regional localization of the human c-ros-1 on 6q22 and flt on 13q12”. Jpn. J. Cancer Res. 78 (8): 772–5. PMID 3115921.
- Birchmeier C, Birnbaum D, Waitches G i dr.. (1986). „Characterization of an activated human ros gene”. Mol. Cell. Biol. 6 (9): 3109–16. PMC 367045. PMID 3785223.
- Sonnenberg-Riethmacher E, Walter B, Riethmacher D i dr.. (1996). „The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis”. Genes Dev. 10 (10): 1184–93. DOI:10.1101/gad.10.10.1184. PMID 8675006.
- Zeng L, Sachdev P, Yan L i dr.. (2001). „Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation”. Mol. Cell. Biol. 20 (24): 9212–24. DOI:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
- Keilhack H, Müller M, Böhmer SA i dr.. (2001). „Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1”. J. Cell Biol. 152 (2): 325–34. DOI:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449.
- Charest A, Kheifets V, Park J i dr.. (2003). „Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma”. Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. DOI:10.1073/pnas.242741799. PMC 298701. PMID 12538861.
- Charest A, Lane K, McMahon K i dr.. (2003). „Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)”. Genes Chromosomes Cancer 37 (1): 58–71. DOI:10.1002/gcc.10207. PMID 12661006.
- Mungall AJ, Palmer SA, Sims SK i dr.. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Légaré C, Sullivan R (2005). „Expression and localization of c-ros oncogene along the human excurrent duct”. Mol. Hum. Reprod. 10 (9): 697–703. DOI:10.1093/molehr/gah087. PMID 15235104.
- Biskup C, Böhmer A, Pusch R i dr.. (2005). „Visualization of SHP-1-target interaction”. J. Cell. Sci. 117 (Pt 21): 5165–78. DOI:10.1242/jcs.01397. PMID 15456853.
- Girish V, Sachdeva N, Minz RW i dr.. (2006). „Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype”. Indian journal of pathology & microbiology 48 (3): 325–30. PMID 16761743.