BW-723C86

BW-723C86
(IUPAC) ime
	5-((thiophen-2-yl)methoxy)-α-methyltryptamine
Klinički podaci
Identifikatori
CAS broj	160521-72-2
ATC kod	?
PubChem	5311036
Hemijski podaci
Formula	C16H18N2OS
Mol. masa	286.391 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3 ; Key: ALFGDCNSEBJYSP-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

BW-723C86 je lek izveden iz triptamina koji deluje kao agonist 5-HT_2B receptora. On pokazuje anksiolitičke efekte u životinjskim studijama,^[3]^[4] a upotrebljavan je i za istraživanje funkcije 5-HT_2B receptora u nizu drugih tkiva.^[5]^[6]^[7]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP (April 1996). „Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety”. British journal of pharmacology 117 (7): 1443–8. PMC 1909458. PMID 8730737.
↑ Kennett G, Trail B, Bright F (December 1998). „Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated”. Neuropharmacology 37 (12): 1603. DOI:10.1016/S0028-3908(98)00115-4. PMID 9886683.
↑ Knowles Ian D, Ramage Andrew G (January 2000). „Evidence that activation of central 5-HT2Breceptors causes renal sympathoexcitation in anaesthetized rats”. British Journal of Pharmacology 129 (1): 177. DOI:10.1038/sj.bjp.0703011. PMC 1621132. PMID 10694218.
↑ G�nther Silke, Maroteaux Luc, Schwarzacher Stephan W. (August 2006). „Endogenous 5-HT2B receptor activation regulates neonatal respiratory activityin vitro”. Journal of Neurobiology 66 (9): 949. DOI:10.1002/neu.20253. PMID 16758492.
↑ Ryan B, Anwyl R, Rowan M (August 2008). „5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress”. Neuropharmacology 55 (2): 175. DOI:10.1016/j.neuropharm.2008.05.006. PMID 18538800.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP (April 1996). „Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety”. British journal of pharmacology 117 (7): 1443–8. PMC 1909458. PMID 8730737.

[4] Kennett G, Trail B, Bright F (December 1998). „Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated”. Neuropharmacology 37 (12): 1603. DOI:10.1016/S0028-3908(98)00115-4. PMID 9886683.

[5] Knowles Ian D, Ramage Andrew G (January 2000). „Evidence that activation of central 5-HT2Breceptors causes renal sympathoexcitation in anaesthetized rats”. British Journal of Pharmacology 129 (1): 177. DOI:10.1038/sj.bjp.0703011. PMC 1621132. PMID 10694218.

[6] G�nther Silke, Maroteaux Luc, Schwarzacher Stephan W. (August 2006). „Endogenous 5-HT2B receptor activation regulates neonatal respiratory activityin vitro”. Journal of Neurobiology 66 (9): 949. DOI:10.1002/neu.20253. PMID 16758492.

[7] Ryan B, Anwyl R, Rowan M (August 2008). „5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress”. Neuropharmacology 55 (2): 175. DOI:10.1016/j.neuropharm.2008.05.006. PMID 18538800.

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