PRX-07034
(Preusmjereno sa stranice BSLXKMCHXRCBIH-UHFFFAOYSA-N)
PRX-07034 je selektivni antagonist 5-HT6 receptora.[3] On utiče na kogniciju, poboljšava memoriju, i potencijalno umanjuje unos hrane i telesnu težinu kod glodara.[3][4][5][6]
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| N-[1-(5-hloro-2,3-dimetoksifenil)etil]-2-metilsulfonil-5-piperazin-1-ilanilin | |||
| Klinički podaci | |||
| Identifikatori | |||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 11532574 | ||
| Hemijski podaci | |||
| Formula | C21H29Cl2N3O4S | ||
| Mol. masa | 490,44 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | Nije kontrolisan | ||
| Način primene | Oralno | ||
Reference
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ 3,0 3,1 „Science Links Japan | PRX-07034, a Potent and Selective 5-HT6 Receptor Antagonist, Reduces Food Intake and Body Weight in Rats”. Arhivirano iz originala na datum 2012-02-29.
- ↑ Fone KC (November 2008). „An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function”. Neuropharmacology 55 (6): 1015–22. DOI:10.1016/j.neuropharm.2008.06.061. PMID 18655798.
- ↑ „Science Links Japan | Combination of sub-threshold doses of Aricept and PRX-07034, a novel 5-HT6 receptor antagonist, enhances Novel Object Discrimination (NOD) memory”. Arhivirano iz originala na datum 2012-02-29.
- ↑ Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE (2007). „Serotonergic drugs : effects on appetite expression and use for the treatment of obesity”. Drugs 67 (1): 27–55. PMID 17209663.
