Arilamin N-acetiltransferaza
Arilamin N-acetiltransferaza (EC 2.3.1.5, arilaminska acetilaza, beta-naftilaminska N-acetiltransferaza, 4-aminobifenilna N-acetiltransferaza, acetil KoA-arilaminska N-acetiltransferaza, 2-naftilaminska N-acetiltransferaza, arilaminska acetiltransferaza, indolaminska N-acetiltransferaza, N-acetiltransferaza, p-aminosalicilatna N-acetiltransferaza, serotoninska acetiltransferaza, serotoninska N-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:arilamin N-acetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Arilamin N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.5 | ||||||||
| CAS broj | 9027-33-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + arilamin KoA + N-acetilarilamin
Ovaj enzim ima široku specifičnost za aromatične amine, uključujući serotonin. On takođe katalizuje acetil-transfer između arila mina bez KoA.
Reference
uredi- ↑ Chou, T.C. and Lipmann, F. (1952). „Separation of acetyl transfer enzymes in pigeon liver extract”. J. Biol. Chem. 196: 89-103. PMID 12980945.
- ↑ Paul, R.C. and Ratledge, C. (1973). „Further studies on anthranilate N-acetylanthranilic acid in Aerobacter aerogenes”. Biochim. Biophys. Acta 320: 9-15. PMID 4748369.
- ↑ Tabor, H., Mehler, A.H. and Stadtman, E.R. (1953). „The enzymatic acetylation of amines”. J. Biol. Chem. 204: 127-138. PMID 13084583.
- ↑ Weissbach, H., Redfield, B.G. and Axelrod, J. (1961). „The enzymic acetylation of serotonin and other naturally occurring amines”. Biochim. Biophys. Acta 54: 190-192. PMID 14005907.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.