Alkan-1-ol dehidrogenaza (akceptor)
Alkan-1-ol dehidrogenaza (akceptor) (EC 1.1.99.20, polietilen glikolna dehidrogenaza, alkan-1-ol:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom alkan-1-ol:akceptor oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Alkan-1-ol dehidrogenaza (akceptor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.20 | ||||||||
| CAS broj | 75496-55-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- primarni alkohol + akceptor aldehid + redukovani akceptor
Ovaj enzim je hinoprotein. On deluje na C3-C16 primarne alkohole linearnog zasićenog lanca, C4-C7 aldehide i na nejonske surfaktante koji sadrže polietilenske glikolne ostatke, kao što su Tween 40 i 60, ali ne na metanol, i veoma sporo na etanol. 2,6-Dihloroindofenol može da služi kao akceptor, cf. EC 1.1.99.8, alkoholna dehidrogenaza (akceptor).
Reference
uredi- ↑ Kawai, F., Kimura, T., Tani, Y., Yamada, H., Ueno, T. and Fukami, H. (1983). „Identification of reaction-products of polyethylene-glycol dehydrogenase”. Agric. Biol. Chem. 47: 1669-1671.
- ↑ Kawai, F., Yamanaka, H., Ameyama, M., Shinagawa, E., Matsushita, K. and Adachi, O. (1985). „Identification of the prosthetic group and further characterization of a novel enzyme, polyethylene-glycol dehydrogenase”. Agric. Biol. Chem. 49: 1071-1076.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.