Aldehid dehidrogenaza (FAD-nezavisna)
Aldehid dehidrogenaza (FAD-nezavisna) (EC 1.2.99.7, aldehidna oksidaza, aldehidna oksidoreduktaza, Mop, AORDd) je enzim sa sistematskim imenom aldehid:akceptor oksidoreduktaza (FAD-nezavisna).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aldehid dehidrogenaza (FAD-nezavisna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.99.7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- aldehid +H2O + akceptor karboksilat + redukovani akceptor
Ovaj enzim pripada familiji ksantinskih oksidaza. Enzim iz Desulfovibrio sp. sadrži molibden-molibdopterin-citozin dinukleotidni (MCD) kompleks i dva tipa [2Fe-2S] klaster po monomeru. On ne sadrži FAD.
Reference uredi
- ↑ Uchida, H., Kondo, D., Yamashita, A., Nagaosa, Y., Sakurai, T., Fujii, Y., Fujishiro, K., Aisaka, K. and Uwajima, T. (2003). „Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690”. FEMS Microbiol. Lett. 229: 31-36. PMID 14659539.
- ↑ Duarte, R.O., Archer, M., Dias, J.M., Bursakov, S., Huber, R., Moura, I., Romao, M.J. and Moura, J.J. (2000). „Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774”. Biochem. Biophys. Res. Commun. 268: 745-749. PMID 10679276.
- ↑ Andrade, S.L., Brondino, C.D., Feio, M.J., Moura, I. and Moura, J.J. (2000). „Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491. EPR assignment of the proximal [2Fe-2S] cluster to the Mo site”. Eur. J. Biochem. 267: 2054-2061. PMID 10727945.
- ↑ Romao, M.J., Archer, M., Moura, I., Moura, J.J., LeGall, J., Engh, R., Schneider, M., Hof, P. and Huber, R. (1995). „Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas”. Science 270: 1170-1176. PMID 7502041.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.