AM-905 je analgetik koji je kanabinoidni agonist sa konformaciono ograničenim bočnim lancom. On je potentan i relativno selektivan agonist CB1 kanabinoidnog receptora, sa Ki od 1,2 nM na CB1 i 5,3 nM naCB2.[5]
AM-905
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| (IUPAC) ime
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| (6aR,9R,10aR)-3-[(E)-hept-1-enil]-9-(hidroksimetil)-6,6-dimetil-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1-ol
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| Klinički podaci
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| Identifikatori
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| ATC kod
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?
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| PubChem[1][2]
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9998522
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| ChemSpider[3]
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8174103
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| ChEMBL[4]
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CHEMBL127848  Y
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| Hemijski podaci
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| Formula
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C23H34O3
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| Mol. masa
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358,513 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C23H34O3/c1-4-5-6-7-8-9-16-13-20(25)22-18-12-17(15-24)10-11-19(18)23(2,3)26-21(22)14-16/h8-9,13-14,17-19,24-25H,4-7,10-12,15H2,1-3H3/b9-8+/t17-,18-,19-/m1/s1 Y
Key: NJIKRWBGUIYKJM-OKMMTOMJSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219
Šablon:Kanabinoidi
