Alanopin dehidrogenaza
(Preusmjereno sa stranice ALPDH)
Alanopin dehidrogenaza (EC 1.5.1.17, ALPDH, alanopin(mezo-N-(1-karboksietil)-alanin)dehidrogenaza, meso-N-(1-karboksietil)-alanin:NAD+ oksidoreduktaza, alanopin: NAD+ oksidoreduktaza, ADH, alanopin:NAD+ oksidoreduktaza) je enzim sa sistematskim imenom 2,2'-iminodipropanoat:NAD+ oksidoreduktaza (formira L-alanin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Alanopin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.17 | ||||||||
| CAS broj | 71343-07-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2,2'-iminodipropanoat + NAD+ +H2O L-alanin + piruvat + NADH + H+
Reakcije teče u reverznom smeru. L-alanin se može zameniti L-cisteinom, L-serinom i L-treoninom. Reakcija sa glicinom je veoma spora, cf. EC 1.5.1.22 strombinska dehidrogenaza.
Reference
uredi- ↑ Dando, P.R. (1981). „Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine dehydrogenase from the mussel Mytilus edulis L”. Biochem. Soc. Trans. 9: 297-298.
- ↑ Fields, J.H.A., Eng, A.K., Ramsden, W.D., Hochachka, P.W. and Weinstein, B. (1980). „Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas”. Arch. Biochem. Biophys. 201: 110-114. PMID 6156653.
- ↑ Fields, J.H.A. and Hochachka, P.W. (1981). „Purification and properties of alanopine dehydrogenase from the adductor muscle of the oyster, Crassostrea gigas (Mollusca, Bivalvia)”. Eur. J. Biochem. 114: 615-621. PMID 7238503.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.