7-Spiroindaniloksimorfon (SIOM) je lek koji se koristi u naučnim istraživanjima. On je selektivni δ-opioidni agonist.[4][5][6][7][8]
7-Spiroindaniloksimorfon
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(IUPAC) ime
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(4aR-(4aα,7aα,8α,9cα))- 1',3',7,7a,8,9- Hexahydro- 3,7a-dihydroxy- 12-methylspiro (6H-8,9c- (iminoethano) phenanthro (4,5-bcd) furan- 6,2'- (2H)inden)- 5(4aH)- one
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Klinički podaci
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Identifikatori
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CAS broj
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150380-34-0
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ATC kod
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?
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PubChem[1][2]
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5487084
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ChemSpider[3]
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8176808
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Hemijski podaci
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Formula
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C25H25NO4
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Mol. masa
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403.470 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C25H25NO4/c1-26-9-8-24-19-14-6-7-17(27)20(19)30-22(24)21(28)23(13-25(24,29)18(26)10-14)11-15-4-2-3-5-16(15)12-23/h2-7,18,22,27,29H,8-13H2,1H3/t18?,22-,24-,25+/m0/s1 Y Key: YJWDKWRVFJZBCJ-OVKCVFHGSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Portoghese PS, Moe ST, Takemori AE (1993). „A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists”. Journal of medicinal chemistry 36 (17): 2572–4. PMID 8394935.
- ↑ Fang X, Larson DL, Portoghese PS (1997). „7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands”. Journal of medicinal chemistry 40 (19): 3064–70. DOI:10.1021/jm970283e. PMID 9301669.
- ↑ Ohkawa S, Digiacomo B, Larson DL, Takemori AE, Portoghese PS (1997). „7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors”. Journal of medicinal chemistry 40 (11): 1720–5. DOI:10.1021/jm9700880. PMID 9171881.
- ↑ Kshirsagar TA, Fang X, Portoghese PS (1998). „14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors”. Journal of medicinal chemistry 41 (14): 2657–60. DOI:10.1021/jm980209b. PMID 9651172.
- ↑ Shenderovich MD, Liao S, Qian X, Hruby VJ (2000). „A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands”. Biopolymers 53 (7): 565–80. DOI:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5. PMID 10766952.
Spoljašnje veze
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