5-ekso-hidroksikamfor dehidrogenaza
5-ekso-hidroksikamfor dehidrogenaza (EC 1.1.1.327, F-dehidrogenaza, FdeH) je enzim sa sistematskim imenom 5-ekso-hidroksikamfor:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 5-ekso-hidroksikamfor dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.327 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5-ekso-hidroksikamfor + NAD+ bornan-2,5-dion + NADH + H+
Ovaj enzim sadrži Zn2+. On je izolovan iz Pseudomonas putida, i učestvuje u degradaciji (+)-kamfora.
Reference uredi
- ↑ Rheinwald, J.G., Chakrabarty, A.M. and Gunsalus, I.C. (1973). „A transmissible plasmid controlling camphor oxidation in Pseudomonas putida”. Proc. Natl. Acad. Sci. USA 70: 885-889. PMID 4351810.
- ↑ Koga, H., Yamaguchi, E., Matsunaga, K., Aramaki, H. and Horiuchi, T. (1989). „Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida”. J. Biochem. 106: 831-836. PMID 2613690.
- ↑ Aramaki, H., Koga, H., Sagara, Y., Hosoi, M. and Horiuchi, T. (1993). „Complete nucleotide sequence of the 5-exo-hydroxycamphor dehydrogenase gene on the CAM plasmid of Pseudomonas putida (ATCC 17453)”. Biochim. Biophys. Acta 1174: 91-94. PMID 8334169.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.