4-Aminobutirat—piruvat transaminaza
4-aminobutirat---piruvat transaminaza (EC 2.6.1.96, aminobutiratna aminotransferaza, gama-aminobutiratna aminotransaminaza, gama-aminobutiratna transaminaza, gama-aminobutirno kiselinskaa aminotransferaza, gama-aminobutirna kiselina piruvatna transaminaza, gama-aminobutirna kiselina transaminaza, gama-aminobutirna transaminaza, 4-aminobutiratna aminotransferaza, 4-aminobutirna kiselina aminotransferaza, aminobutiratna transaminaza, GABA aminotransferaza, GABA transaminaza, GABA transferaza, POP2 (gen)) je enzim sa sistematskim imenom 4-aminobutanoat:piruvat aminotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-aminobutirat---piruvat transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.96 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) 4-aminobutanoat + piruvat sukcinat semialdehid + L-alanin
- (2) 4-aminobutanoat + glioksilat sukcinat semialdehid + glicin
Za rad ovog enzima je neophodan piridoksal 5'-fosfat.
Reference
uredi- ↑ Van Cauwenberghe, O.R. and Shelp, B.J. (1999). „Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum”. Phytochemistry 52: 575-581.
- ↑ Palanivelu, R., Brass, L., Edlund, A.F. and Preuss, D. (2003). „Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels”. Cell 114: 47-59. PMID 12859897.
- ↑ Clark, S.M., Di Leo, R., Dhanoa, P.K., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis γ-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate”. J. Exp. Bot. 60: 1743-1757. PMID 19264755.
- ↑ Clark, S.M., Di Leo, R., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate”. J. Exp. Bot. 60: 3255-3267. PMID 19470656.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.