Zn2+ eksportujuća ATPaza
Zn2+ eksportujuća ATPaza (EC 3.6.3.5, Zn(II)-translocirajuća P-tip ATPaza, P1B-tip ATPaza, AtHMA4) je enzim sa sistematskim imenom ATP fosfohidrolaza (Zn2+ eksport).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Zn2+ eksportujuća ATPaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.3.5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ova P-tip ATPaza podleže kovalentnoj fosforilaciji tokom transportnog ciklusa.
Reference
uredi- ↑ Beard, S.J., Hashim, R., Membrillo-Hernández, J., Hughes, M.N. and Poole, R.K. (1997). „Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase”. Mol. Microbiol. 25: 883-891. PMID 9364914.
- ↑ Rensing, C., Mitra, B. and Rosen, B.P. (1997). „The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase”. Proc. Natl. Acad. Sci. USA 94: 14326-14331. PMID 9405611.
- ↑ Rensing, C., Sun, Y., Mitra, B. and Rosen, B.P. (1998). „Pb(II)-translocating P-type ATPases”. J. Biol. Chem. 273: 32614-32617. PMID 9830000.
- ↑ Mills, R.F., Francini, A., Ferreira da Rocha, P.S., Baccarini, P.J., Aylett, M., Krijger, G.C. and Williams, L.E. (2005). „The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels”. FEBS Lett. 579: 783-791. PMID 15670847.
- ↑ Eren, E. and Argüello, J.M. (2004). „Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis”. Plant Physiol. 136: 3712-3723. PMID 15475410.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.