Timin-DNK glikozilaza
(Preusmjereno sa stranice Za neusklađenost specifična timin-DNK glikozilaza)
Timin-DNK glikozilaza (EC 3.2.2.29, za neusklađenost specifična timin-DNK glikozilaza, za neusklađenost specifična timin-DNK N-glikozilaza, hTDG, hsTDG, TDG, timinska DNK glikozilaza, G/T glikozilaza, uracil/timin DNK glikozilaza, T:G za neusklađenost specifična timidin-DNK glikozilaza, G:T za neusklađenost specifična timinska DNK-glikozilaza) je enzim sa sistematskim imenom timin-DNK dezoksiribohidrolaza (otpuštanje timina).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Timin-DNK glikozilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.2.29 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa timin
Zimin-DNK glikozilaza je deo mehanizma za popravku DNK.
Reference
uredi- ↑ Waters, T.R. and Swann, P.F. (2000). „Thymine-DNA glycosylase and G to A transition mutations at CpG sites”. Mutat. Res. 462: 137-147. PMID 10767625.
- ↑ Neddermann, P. and Jiricny, J. (1993). „The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells”. J. Biol. Chem. 268: 21218-21224. PMID 8407958.
- ↑ Waters, T.R. and Swann, P.F. (1998). „Kinetics of the action of thymine DNA glycosylase”. J. Biol. Chem. 273: 20007-20014. PMID 9685338.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.