Vibriolizin
Vibriolizin (EC 3.4.24.25, Aeromonas proteolytica neutralna proteinaza, aeromonolizin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Vibriolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.25 | ||||||||
| CAS broj | 69598-88-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Preferentno razlaganje veza sa glomaznim hidrofobnim grupama u P2 i P1'. Phe u P1' je preferentni ostatak, po čemu se ovaj enzim razlikuje od termolizina
Ovaj termostablni enzim je prisutan u Vibrio proteolyticus.
Reference
uredi- ↑ Holmquist, B. and Vallee, B.L. (1976). „Esterase activity of zinc neutral proteases”. Biochemistry 15: 101-107. PMID 2276.
- ↑ Wilkes, S.H. and Prescott, J.M. (1976). „Aeromonas neutral protease”. Methods Enzymol. 45: 404-415. PMID 1012006.
- ↑ Bayliss, M.E., Wilkes, S.H. and Prescott, J.M. (1980). „Aeromonas neutral protease: specificity toward extended substrates”. Arch. Biochem. Biophys. 204: 214-219. PMID 7000005.
- ↑ Wilkes, S.H., Bayliss, M.E. and Prescott, J.M. (1988). „Critical ionizing groups in Aeromonas neutral protease”. J. Biol. Chem. 263: 1821-1825. PMID 3123480.
- ↑ David, V.A., Deutch, A.H., Sloma, A., Pawlyk, D., Ally, A. and Durham, D.R. (1992). „Cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of Vibrio proteolyticus”. Gene 112: 107-112. PMID 1551587.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.