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U-plasminogeni aktivator

(Preusmjereno sa Urokinaza)

U-plasminogeni aktivator (EC 3.4.21.73, urokinaza, urinarni plazminogenski aktivator, ćelijski plazminogenski aktivator, urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, urokinazni plazminogenski aktivator, uPA, u-PA, abokinaza, urinarna esteraza A) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

U-plasminogeni aktivator
Identifikatori
EC broj 3.4.21.73
CAS broj 9039-53-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Specifično razlaganje Arg-Val veze u plasminogenu čime se formira plazmin

Ovaj enzim se formira iz neaktivnog prekursora posredstvom plazmina ili kalikreina plazme.

ReferenceUredi

  1. Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L. (1981). "Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates". Methods Enzymol. 80: 341–361. PMID 6210826. 
  2. Loskutoff, D.J. and Schleef, R.R. (1988). "Plasminogen activators and their inhibitors". Methods Enzymol. 163: 293–302. PMID 3148826. 
  3. Saksela, O. and Rifkin, D.B. (1988). "Cell-associated plasminogen activation: regulation and physiological functions". Annu. Rev. Cell Biol. 4: 93–126. PMID 3143380. 
  4. Collen, D., Lijnen, H. R. and Verstraete, M. (1990). "The fibrinolytic system and its disorders". u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 
  5. Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D. (1990). "Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Glu)". J. Biol. Chem. 265: 5232–5236. PMID 1969415. 

LiteraturaUredi

  • Collen, D., Lijnen, H. R. and Verstraete, M. (1990). "The fibrinolytic system and its disorders". u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -. 

Spoljašnje vezeUredi