U-plasminogeni aktivator
(Preusmjereno sa stranice Urokinaza)
U-plasminogeni aktivator (EC 3.4.21.73, urokinaza, urinarni plazminogenski aktivator, ćelijski plazminogenski aktivator, urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, urokinazni plazminogenski aktivator, uPA, u-PA, abokinaza, urinarna esteraza A) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| U-plasminogeni aktivator | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.73 | ||||||||
| CAS broj | 9039-53-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Specifično razlaganje Arg-Val veze u plasminogenu čime se formira plazmin
Ovaj enzim se formira iz neaktivnog prekursora posredstvom plazmina ili kalikreina plazme.
Reference
uredi- ↑ Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L. (1981). „Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates”. Methods Enzymol. 80: 341-361. PMID 6210826.
- ↑ Loskutoff, D.J. and Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293-302. PMID 3148826.
- ↑ Saksela, O. and Rifkin, D.B. (1988). „Cell-associated plasminogen activation: regulation and physiological functions”. Annu. Rev. Cell Biol. 4: 93-126. PMID 3143380.
- ↑ Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.
- ↑ Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D. (1990). „Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Glu)”. J. Biol. Chem. 265: 5232-5236. PMID 1969415.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.