Uracil-DNK glikozilaza
Uracil-DNK glikozilaza (EC 3.2.2.27, UdgB, uracil-DNK N-glikozilaza, UDG, uracil DNK glikohidrolaza) je enzim sa sistematskim imenom uracil-DNK dezoksiribohidrolaza (otpuštanje uracila).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Uracil-DNK glikozilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.2.2.27 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Uracil-DNK glikozilaze su široko rasprostranjeni enzimi.
Reference
uredi- ↑ Lee, M.S., Kim, G.A., Seo, M.S., Lee, J.H. and Kwon, S.T. (2009). „Characterization of heat-labile uracil-DNA glycosylase from Psychrobacter sp. HJ147 and its application to the polymerase chain reaction”. Biotechnol. Appl. Biochem. 52: 167-175. PMID 18412541.
- ↑ Kim, G.A., Lee, M.S., Sun, Y., Lee, B.D., Lee, J.I., Lee, J.H. and Kwon, S.T. (2008). „Characterization of cold-active uracil-DNA glycosylase from Bacillus sp. HJ171 and its use for contamination control in PCR”. Appl. Microbiol. Biotechnol. 80: 785-794. PMID 18626641.
- ↑ Parikh, S.S., Putnam, C.D. and Tainer, J.A. (2000). „Lessons learned from structural results on uracil-DNA glycosylase”. Mutat. Res. 460: 183-199. PMID 10946228.
- ↑ Stivers, J.T. and Drohat, A.C. (2001). „Uracil DNA glycosylase: insights from a master catalyst”. Arch. Biochem. Biophys. 396: 1-9. PMID 11716455.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.