Uracil-DNK glikozilaza

(Preusmjereno sa stranice UdgB)

Uracil-DNK glikozilaza (EC 3.2.2.27, UdgB, uracil-DNK N-glikozilaza, UDG, uracil DNK glikohidrolaza) je enzim sa sistematskim imenom uracil-DNK dezoksiribohidrolaza (otpuštanje uracila).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Uracil-DNK glikozilaza
Identifikatori
EC broj 3.2.2.27
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
hidroliza jednolančane DNK ili neuklađene dvolančane DNK i polinukleotida čime se oslobađa uracil

Uracil-DNK glikozilaze su široko rasprostranjeni enzimi.

Reference uredi

  1. Lee, M.S., Kim, G.A., Seo, M.S., Lee, J.H. and Kwon, S.T. (2009). „Characterization of heat-labile uracil-DNA glycosylase from Psychrobacter sp. HJ147 and its application to the polymerase chain reaction”. Biotechnol. Appl. Biochem. 52: 167-175. PMID 18412541. 
  2. Kim, G.A., Lee, M.S., Sun, Y., Lee, B.D., Lee, J.I., Lee, J.H. and Kwon, S.T. (2008). „Characterization of cold-active uracil-DNA glycosylase from Bacillus sp. HJ171 and its use for contamination control in PCR”. Appl. Microbiol. Biotechnol. 80: 785-794. PMID 18626641. 
  3. Parikh, S.S., Putnam, C.D. and Tainer, J.A. (2000). „Lessons learned from structural results on uracil-DNA glycosylase”. Mutat. Res. 460: 183-199. PMID 10946228. 
  4. Stivers, J.T. and Drohat, A.C. (2001). „Uracil DNA glycosylase: insights from a master catalyst”. Arch. Biochem. Biophys. 396: 1-9. PMID 11716455. 

Literatura uredi

Spoljašnje veze uredi