UTP-heksoza-1-fosfat uridililtransferaza
UTP-heksoza-1-fosfat uridililtransferaza (EC 2.7.7.10, galaktoza-1-fosfatna uridililtransferaza, galaktoza 1-fosfatna uridililtransferaza, alfa-D-galaktoza 1-fosfat uridililtransferaza, galaktoza 1-fosfatna uridiltransferaza, UDPgalaktoza pirofosforilaza, uridin difosfat galaktozna pirofosforilaza, uridin difosfogalaktozna pirofosforilaza) je enzim sa sistematskim imenom UTP:alfa-D-heksoza-1-fosfat uridililtransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UTP-heksoza-1-fosfat uridililtransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| UTP-heksoza-1-fosfat uridililtransferaza homodimer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.10 | ||||||||
| CAS broj | 2599380 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- UTP + alfa-D-galaktoza 1-fosfat difosfat + UDP-alfa-D-galaktoza
Alfa-D-glukoza 1-fosfat takođe može da deluje kao akceptor, mada sporije.
Reference
uredi- ↑ Isselbacher, K.J. (1958). „A mammalian uridinediphosphate galactose pyrophosphorylase”. J. Biol. Chem. 232: 429-444. PMID 13549431.
- ↑ Kalckar, H.M. (1953). „The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides”. Biochim. Biophys. Acta 12: 250-264. PMID 13115434.
- ↑ Lee, L., Kimura, A. and Tochikura, T. (1979). „Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum”. J. Biochem. (Tokyo) 86: 923-928. PMID 500588.
- ↑ Lobelle-Rich, P.A. and Reeves, R.E. (1983). „Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica”. Mol. Biochem. Parasitol. 7: 173-182. PMID 6304512.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.