UDP-N-acetilmuramoilalanil-D-glutamat-2,6-diamino-pimelatna ligaza
UDP-N-acetilmuramoilalanil-D-glutamat-2,6-diamino-pimelatna ligaza (EC 6.3.2.13, MurE sintetaza, UDP-N-acetilmuramoil-L-alanil-D-glutamat:meso-2,6-diamino-heptanedioat ligaza (formira ADP), UDP-N-acetilmuramoil-L-alanil-D-glutamil-meso-2,6-diaminopimelat sintetaza, UDP-N-acetilmuramoilalanil-D-glutamat—2,6-diaminopimelat ligaza) je enzim sa sistematskim imenom UDP-N-acetilmuramoil-L-alanil-D-glutamat:meso-2,6-diaminoheptandioat gama-ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N-acetilmuramoilalanil-D-glutamat-2,6-diamino-pimelatna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.13 | ||||||||
| CAS broj | 2620865 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + UDP-N-acetilmuramoil-L-alanil-D-glutamat + meso-2,6-diaminoheptanedioat ADP + fosfat + UDP-N-acetilmuramoil-L-alanil-D-gama-glutamil-meso-2,6-diaminoheptanedioat
Ovaj enzim učestvuje u sintezi peptida ćelijskog zida.
Reference uredi
- ↑ Mizuno, Y. and Ito, E. (1968). „Purification and properties of uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase”. J. Biol. Chem. 243: 2665-2672. PMID 4967958.
- ↑ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.