UDP-N-acetilmuramat-L-alaninska ligaza
UDP-N-acetilmuramat-L-alaninska ligaza (EC 6.3.2.8, MurC sintetaza, UDP-N-acetilmuramoil-L-alanin sintetaza, uridin difosfo-N-acetilmuramoilalanin sintetaza, UDP-N-acetilmuramoilalanin sintetaza, enzim dodavanja L-alanina, UDP-acetilmuramil-L-alanin sintetaza, UDPMurNAc-L-alanin sintetaza, L-Ala ligaza, uridin difosfat N-acetilmuramat:L-alanin ligaza, uridin 5'-difosfat-N-acetilmuramil-L-alanin sintetaza, uridin-difosfat-N-acetilmuramat:L-alanin ligaza, UDP-MurNAc:L-alanin ligaza, enzim dodavanja alanina, UDP-N-acetilmuramil:L-alanin ligaza) je enzim sa sistematskim imenom UDP-N-acetilmuramat:L-alanin ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N-acetilmuramat-L-alaninska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.8 | ||||||||
| CAS broj | 9023-52-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim učestvuje u sintezi peptida ćelijskog zida.
Reference
uredi- ↑ Ito, E. and Strominger, J.L. (1962). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine”. J. Biol. Chem. 237: 2689-2695.
- ↑ Nathenson, S.G., Strominger, J.L. and Ito, E. (1964). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. IV. Purification and properties of D-glutamic acid-adding enzyme”. J. Biol. Chem. 239: 1773-1776. PMID 14213349.
- ↑ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.