UDP-N-acetilglukozaminska 4,6-dehidrataza (zadržavanje konfiguracije)
UDP-N-acetilglukozaminska 4,6-dehidrataza (zadržavanje konfiguracije) (EC 4.2.1.135, PglF) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin hidrolijaza (zadržava konfiguraciju, formira UDP-2-acetamido-2,6-didezoksi-alfa-D-ksilo-heks-4-uloza).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N-acetilglukozaminska 4,6-dehidrataza (zadržavanje konfiguracije) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.135 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-alfa-D-glukozamin UDP-2-acetamido-2,6-didezoksi-alfa-D-ksilo-heks-4-uloza + H2O
Ovaj enzim sadrži NAD+ kao kofaktor.
Reference uredi
- ↑ Schoenhofen, I.C., McNally, D.J., Vinogradov, E., Whitfield, D., Young, N.M., Dick, S., Wakarchuk, W.W., Brisson, J.R. and Logan, S.M. (2006). „Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways”. J. Biol. Chem. 281: 723-732. PMID 16286454.
- ↑ Olivier, N.B., Chen, M.M., Behr, J.R. and Imperiali, B. (2006). „In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system”. Biochemistry 45: 13659-13669. PMID 17087520.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.