N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza
(Preusmjereno sa stranice UDP-N-acetil-D-galaktozamin:N-acetil-beta-D-glukozaminil-grupa 4-beta-N-acetilgalaktozaminiltransferaza)
N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza (EC 2.4.1.244, beta1,4-N-acetilgalaktozaminiltransferaza III, beta4GalNAc-T3, beta1,4-N-acetilgalaktozaminiltransferaza IV, beta4GalNAc-T4, UDP-N-acetil-D-galaktozamin:N-acetil-D-glukozaminil-grupa beta-1,4-N-acetilgalaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:N-acetil-beta-D-glukozaminil-grupa 4-beta-N-acetilgalaktozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N-acetil-beta-glukozaminil-glikoprotein 4-beta-N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.244 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-galaktozamin + N-acetil-beta-D-glukozaminilna grupa UDP + N-acetil-beta-D-galaktozaminil-(1->4)-N-acetil-beta-D-glukozaminilna grupa
Ljudski enzim može da prenese N-acetil-D-galaktozamin (GalNAc) na N-glikanski i O-glikanski supstrat koji ima N-acetil-D-glukozamin (GlcNAc).
Reference uredi
- ↑ Sato, T., Gotoh, M., Kiyohara, K., Kameyama, A., Kubota, T., Kikuchi, N., Ishizuka, Y., Iwasaki, H., Togayachi, A., Kudo, T., Ohkura, T., Nakanishi, H. and Narimatsu, H. (2003). „Molecular cloning and characterization of a novel human β1,4-N-acetylgalactosaminyltransferase, β4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, GalNAc β1-4GlcNAc”. J. Biol. Chem. 278: 47534-47544. PMID 12966086.
- ↑ Gotoh, M., Sato, T., Kiyohara, K., Kameyama, A., Kikuchi, N., Kwon, Y.D., Ishizuka, Y., Iwai, T., Nakanishi, H. and Narimatsu, H. (2004). „Molecular cloning and characterization of β1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine”. FEBS Lett. 562: 134-140. PMID 15044014.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.