UDP-N,N'-diacetilbacilozaminska 2-epimeraza (hidroliza)
(Preusmjereno sa stranice UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising))
UDP-N,N'-diacetilbacilozaminska 2-epimeraza (hidroliza) (EC 3.2.1.184, UDP-Bac2Ac4Ac 2-epimeraza, NeuC) je enzim sa sistematskim imenom UDP-N,N'-diacetilbacilozaminska hidrolaza (2-epimerizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N,N'-diacetilbacilozaminska 2-epimeraza (hidroliza) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.184 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N,N'-diacetilbacilozamin + H2O UDP + 2,4-diacetamido-2,4,6-tridezoksi-D-manopiranoza
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference
uredi- ↑ Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). „Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila”. Biochemistry 47: 3272-3282. PMID 18275154.
- ↑ Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). „The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors”. Glycobiology 19: 715-725. PMID 19282391.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.