UDP-N-acetilglukozamin 6-dehidrogenaza
(Preusmjereno sa stranice UDP-GlcNAc dehidrogenaza)
UDP-N-acetilglukozamin 6-dehidrogenaza (EC 1.1.1.136, uridin difosfoacetilglukozaminska dehidrogenaza, UDP-acetilglukozaminska dehidrogenaza, UDP-2-acetamido-2-dezoksi-D-glukoza:NAD oksidoreduktaza, UDP-GlcNAc dehidrogenaza, WbpA, WbpO) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin:NAD+ 6-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N-acetilglukozamin 6-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.136 | ||||||||
| CAS broj | 9054-83-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-alfa-D-glukozamin + 2 NAD+ +H2O UDP-N-acetil-2-amino-2-dezoksi-alfa-D-glukuronat + 2 NADH + 2 H+
Ovaj enzim učestvuje u biosintetičkom putu za UDP-alfa-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronsku kiselinu), značajnom prekursoru lipopolisaharida.
Reference
uredi- ↑ Fan, D.-F., John, C.E., Zalitis, J. and Feingold, D.S. (1969). „UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum”. Arch. Biochem. Biophys. 135: 45-49. PMID 4312076.
- ↑ Miller, W.L., Wenzel, C.Q., Daniels, C., Larocque, S., Brisson, J.R. and Lam, J.S. (2004). „Biochemical characterization of WbpA, a UDP-N-acetyl-D-glucosamine 6-dehydrogenase involved in O-antigen biosynthesis in Pseudomonas aeruginosa PAO1”. J. Biol. Chem. 279: 37551-37558. PMID 15226302.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.