N-acetillaktozaminid b-1,6-N-acetilglukozaminil-transferaza

N-acetillaktozaminid b-1,6-N-acetilglukozaminil-transferaza
Identifikatori
EC broj	2.4.1.150
CAS broj	85638-40-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

N-acetillaktozaminid b-1,6-N-acetilglukozaminil-transferaza (EC 2.4.1.150, N-acetilglukozaminiltransferaza, uridin difosfoacetilglukozamin-acetillaktozaminid beta1->6-acetilglukozaminiltransferaza, Galbeta1->4GlcNAc-R beta1->6 N-acetilglukozaminiltransferaza, UDP-GlcNAc:Gal-R, beta-D-6-N-acetilglukozaminiltransferazal UDP-N-acetil-D-glukozamin:beta-D-galaktozil-1,4-N-acetil-D-glukozaminid beta-1,6-N-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-N-acetil-D-glukozaminid 6-beta-N-acetil-D-glukozaminiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-galaktozil-(1->4)-N-acetil-D-glukozaminil-R

\rightleftharpoons

UDP + N-acetil-beta-D-glukozaminil-(1->6)-beta-D-galaktozil-(1->4)-N-acetil-D-glukozaminil-R

Ovaj enzim deluje na beta-galaktozil-1,4-N-acetilglukozaminil terminus na asialo-alfa1-kiselinskom glikoproteinu.

Reference uredi

↑ Van den Eijnden, D.H., Winterwerp, H., Smeeman, P. and Schiphorst, W.E.C.M. (1983). „Novikoff ascites tumor cells contain N-acetyllactosaminide β1→3 and β1→6 N-acetylglucosaminyltransferase activity”. J. Biol. Chem. 258: 3435-3437. PMID 6219989.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze uredi

MeSH N-acetyllactosaminide+beta-1,6-N-acetylglucosaminyl-transferase

[1] Van den Eijnden, D.H., Winterwerp, H., Smeeman, P. and Schiphorst, W.E.C.M. (1983). „Novikoff ascites tumor cells contain N-acetyllactosaminide β1→3 and β1→6 N-acetylglucosaminyltransferase activity”. J. Biol. Chem. 258: 3435-3437. PMID 6219989.

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