Polipeptid N-acetilgalaktozaminiltransferaza
Polipeptid N-acetilgalaktozaminiltransferaza (EC 2.4.1.41, protein-UDP acetilgalaktozaminiltransferaza, UDP-GalNAc:polipeptid N-acetilgalaktozaminil transferaza, UDP-N-acetilgalaktozamin:kappa-casein polipeptid N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-glikoprotein acetilgalaktozaminiltransferaza, glikoprotein acetilgalaktozaminiltransferaza, polipeptid-N-acetilgalaktozamin transferaza, UDP-acetilgalaktozamin-glikoprotein acetilgalaktozaminiltransferaza, UDP-acetilgalaktozamin:peptid-N-galaktozaminiltransferaza, UDP-GalNAc:polipeptid N-acetilgalaktozaminiltransferaza, UDP-N-acetil-alfa-D-galaktozamin:polipeptid N-acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin-glikoprotein N-acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin-protein N-acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin:polipeptid N-acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin:protein N-acetilgalaktozaminil transferaza, ppGalNAc-T) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-galaktozamin:polipeptid N-acetilgalaktozaminil-transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Polipeptid N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.41 | ||||||||
| CAS broj | 9075-15-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-alfa-D-galaktozamin + polipeptid UDP + N-acetil-alfa-D-galaktozaminil-polipeptid
Za rad ovog enzima su neophodni Mn2+ i Ca2+.
Reference uredi
- ↑ Sugiura, M., Kawasaki, T. and Yamashina, I. (1982). „Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66”. J. Biol. Chem. 257: 9501-9507. PMID 6809738.
- ↑ Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H. (1985). „Purification and characterization of UDP-N-acetylgalactosamine-κ-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow”. Agric. Biol. Chem. 49: 1059-1069.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.