Ksilozilprotein 4-b-galaktoziltransferaza
(Preusmjereno sa stranice UDP-D-galactose:xylose galactosyltransferase)
Ksilozilprotein 4-b-galaktoziltransferaza (EC 2.4.1.133, UDP-D-galaktoza:D-ksiloza galaktoziltransferaza, UDP-D-galaktoza:ksiloza galaktoziltransferaza, galaktoziltransferaza I, uridin difosfogalaktoza-ksiloza galaktoziltransferaza, UDP-galaktoza:O-beta-D-ksilozilprotein 4-beta-D-galaktoziltransferaza, UDP-alfa-D-galaktoza:O-beta-D-ksilozilprotein 4-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:O-beta-D-ksilosil-(protein) 4-beta-D-galaktoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ksilozilprotein 4-b-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.133 | ||||||||
| CAS broj | 52227-72-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-alfa-D-galaktoza + O-beta-D-ksilozil-[protein] UDP + 4-beta-D-galaktozil-O-beta-D-ksilozil-[protein]
Ovaj enzim učestvuje u biosintezi veznog regiona glikozaminoglikanskih lanaca tokom proteoglikanske biosinteze (hondroitin, dermatan i heparan sulfati). Za njegov rad je neophodan Mn2+.
Reference uredi
- ↑ Schwartz, N.B. and Roden, L. (1975). „Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltransferase”. J. Biol. Chem. 250: 5200-5207. PMID 1150655.
- ↑ Okajima, T., Yoshida, K., Kondo, T. and Furukawa, K. (1999). „Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. J. Biol. Chem. 274: 22915-22918. PMID 10438455.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.