UDP-sulfohinovozna sintaza
(Preusmjereno sa stranice UDP-6-sulfo-6-dezoksiglukoza sulfohidrolaza)
UDP-sulfohinovozna sintaza (EC 3.13.1.1, sulfit:UDP-glukoza sulfotransferaza, UDPsulfokvinovozna sintaza) je enzim sa sistematskim imenom UDP-6-sulfo-6-dezoksiglukoza sulfohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-sulfohinovozna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.13.1.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-alfa-D-glukoza + sulfit UDP-alfa-D-sulfokvinovopiranoza + H2O
Za dejstvo ovog enzima je neophodan NAD+.
Reference uredi
- ↑ Essigmann, B., Gler, S., Narang, R.A., Linke, D. and Benning, C. (1998). „Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA 95: 1950-1955. PMID 9465123.
- ↑ Essigmann, B., Hespenheide, B.M., Kuhn, L.A. and Benning, C. (1999). „Prediction of the active-site structure and NAD+ binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis”. Arch. Biochem. Biophys. 369: 30-41. PMID 10462438.
- ↑ Mulichak, A.M., Theisen, M.J., Essigmann, B., Benning, C. and Garavito, R.M. (1999). „Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose”. Proc. Natl. Acad. Sci. USA 96: 13097-13102. PMID 10557279.
- ↑ Sanda, S., Leustek, T., Theisen, M., Garavito, R.M. and Benning, C. (2001). „Recombinant Arabidopsis SQD1 converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro”. J. Biol. Chem. 276: 3941-3946. PMID 11073956.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.