UDP-4-amino-4-dezoksi-L-arabinoza aminotransferaza
UDP-4-amino-4-dezoksi-L-arabinoza aminotransferaza (EC 2.6.1.87, UDP-(beta-L-treo-pentapiranozil-4-uloza difosfat) aminotransferaza, UDP-4-amino-4-dezoksi-L-arabinoza---oksoglutarat aminotransferaza, UDP-Ara4O aminotransferaza, UDP-L-Ara4N transaminaza) je enzim sa sistematskim imenom UDP-4-amino-4-dezoksi-beta-L-arabinoza:2-oksoglutarat aminotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-4-amino-4-dezoksi-L-arabinoza aminotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.87 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-4-amino-4-dezoksi-beta-L-arabinopiranoza + 2-oksoglutarat UDP-beta-L-treo-pentapiranoz-4-uloza + L-glutamat
Ovaj enzim je piridoksal 5'-fosfatni enzim.
Reference
uredi- ↑ Breazeale, S.D., Ribeiro, A.A. and Raetz, C.R. (2003). „Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose”. J. Biol. Chem. 278: 24731-24739. PMID 12704196.
- ↑ Noland, B.W., Newman, J.M., Hendle, J., Badger, J., Christopher, J.A., Tresser, J., Buchanan, M.D., Wright, T.A., Rutter, M.E., Sanderson, W.E., Muller-Dieckmann, H.J., Gajiwala, K.S. and Buchanan, S.G. (2002). „Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme”. Structure 10: 1569-1580. PMID 12429098.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.