UDP-2-acetamido-2-dezoksi-ribo-heksuluronat aminotransferaza
UDP-2-acetamido-2-dezoksi-ribo-heksuluronat aminotransferaza (EC 2.6.1.98, WbpE, WlbC) je enzim sa sistematskim imenom UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat:2-oksoglutarat aminotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-2-acetamido-2-dezoksi-ribo-heksuluronat aminotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.98 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-2-acetamido-3-amino-2,3-didezoksi-alfa-D-glukuronat + 2-oksoglutarat UDP-2-acetamido-2-dezoksi-alfa-D-ribo-heks-3-uluronat + L-glutamat
Ovaj enzim je piridoksal 5'-fosfatni protein. On učestvujeu u biosintezi UDP-alfa-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-didezoksi-alfa-D-manuronske kiseline).
Reference uredi
- ↑ Westman, E.L., McNally, D.J., Charchoglyan, A., Brewer, D., Field, R.A. and Lam, J.S. (2009). „Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa”. J. Biol. Chem. 284: 11854-11862. PMID 19282284.
- ↑ Larkin, A. and Imperiali, B. (2009). „Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1”. Biochemistry 48: 5446-5455. PMID 19348502.
- ↑ Larkin, A., Olivier, N.B. and Imperiali, B. (2010). „Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly”. Biochemistry 49: 7227-7237. PMID 20604544.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.