UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije)
(Preusmjereno sa stranice UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose-forming))
UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije) (EC 4.2.1.115, FlaA1, UDP-N-acetilglukozamin 5-invertujuća 4,6-dehidrataza, PseB, UDP-N-acetilglukozaminska hidrolijaza (vrši inverziju, formira UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza)) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin hidrolijaza (inverzija, formira UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.115 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-alfa-D-glukozamin UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza + H2O
Ovaj enzim dasrži NADP+ kao kofaktor.
Reference uredi
- ↑ Ishiyama, N., Creuzenet, C., Miller, W.L., Demendi, M., Anderson, E.M., Harauz, G., Lam, J.S. and Berghuis, A.M. (2006). „Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity”. J. Biol. Chem. 281: 24489-24495. PMID 16651261.
- ↑ Schirm, M., Soo, E.C., Aubry, A.J., Austin, J., Thibault, P. and Logan, S.M. (2003). „Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori”. Mol. Microbiol. 48: 1579-1592. PMID 12791140.
- ↑ Schoenhofen, I.C., McNally, D.J., Brisson, J.R. and Logan, S.M. (2006). „Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction”. Glycobiology 16: 8C-14C. PMID 16751642.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.