Tuberkulozinolna sintaza
Tuberkulozinolna sintaza (EC 3.1.7.8, Rv3378c) je enzim sa sistematskim imenom tuberculosinil difosfat difosfohidrolaza (formira tuberkulozinol).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tuberkulozinolna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.7.8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tuberkulozinul difosfat + H2O tuberkulozinol + difosfat
Ovaj enzim je jedino prisutan u vrstama Mycobacteria koje uzrokuju tuberkulozu.
Reference
uredi- ↑ Nakano, C., Ootsuka, T., Takayama, K., Mitsui, T., Sato, T. and Hoshino, T. (2011). „Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome”. Biosci. Biotechnol. Biochem. 75: 75-81. PMID 21228491.
- ↑ Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y. and Hara, T. (2011). „Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis”. Org. Biomol. Chem. 9: 2156-2165. PMID 21290071.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.