Triptofan a,b-oksidaza
Triptofan a,b-oksidaza (EC 1.3.3.10, L-triptofan 2',3'-oksidaza, L-triptofan alfa,beta-dehidrogenaza) je enzim sa sistematskim imenom L-triptofan:kiseonik alfa,beta-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Triptofan a,b-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.10 | ||||||||
| CAS broj | 156859-19-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-triptofan + O2 alfa,beta-didehidrotriptofan + H2O2
Za rad ovog enzima je neohodan Hem. Enzim iz Chromobakterija violaceum je specifičan za triptofanske derivate sa slobodnom karboksilnom grupom, kao i za amide i estre.
Reference
uredi- ↑ Genet, R., Denoyelle, C. and Menez, A. (1994). „Purification and partial characterization of an amino acid α,β-dehydrogenase, L-tryptophan 2′,3′-oxidase from Chromobacterium violaceum”. J. Biol. Chem. 269: 18177-18184. PMID 8027079.
- ↑ Genet, R., Benetti, P.H., Hammadi, A. and Menez, A. (1995). „L-Tryptophan 2′,3′-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications”. J. Biol. Chem. 270: 23540-23545. PMID 7559518.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.