Tripeptidilna peptidaza I
Tripeptidilna peptidaza I (EC 3.4.14.9, tripeptidilna aminopeptidaza, tripeptidilna peptidaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tripeptidilna peptidaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.14.9 | ||||||||
| CAS broj | 151662-36-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Odvajanje N-terminalnog tripeptida sa polipeptida. Takođe deluje kao endopeptidaza.
Ovaj lizozomalni enzim je aktivan pri kiselom pH.
Reference
uredi- ↑ Ezaki, J., Tanida, I., Kanehagi, N. and Kominami, E. (1999). „A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase”. J. Neurochem. 72: 2573-2582. PMID 10349869.
- ↑ Rawlings, N.D. and Barrett, A.J. (1999). „Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis”. Biochim. Biophys. Acta 1429: 496-500. PMID 9989235.
- ↑ Ezaki, J., Takeda-Ezaki, M., Oda, K. and Kominami, E. (2000). „Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis”. Biochem. Biophys. Res. Commun. 268: 904-908. PMID 10679303.
- ↑ Junaid, M.A., Wu, G.X. and Pullarkat, R.K. (2000). „Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis”. J. Neurochem. 74: 287-294. PMID 10617131.
- ↑ Lin, L., Sohar, I., Lackland, H. and Lobel, P. (2001). „The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH”. J. Biol. Chem. 276: 2249-2255. PMID 11054422.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.