Trihodienska sintaza
Trihodienska sintaza (EC 4.2.3.6, trihodienska sintetaza, seskviterpenska ciklaza, trans,trans-farnezil-difosfat seskviterpenoid-lijaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira trihodien).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Trihodienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.6 | ||||||||
| CAS broj | 101915-76-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat trihodien + difosfat
Reference uredi
- ↑ Hohn, T.M. and Vanmiddlesworth, F. (1986). „Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides”. Arch. Biochem. Biophys. 251: 756-761. PMID 3800398.
- ↑ Hohn, T.M. and Beremand, P.D. (1989). „Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides”. Gene 79: 131-138. PMID 2777086.
- ↑ Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W. (2001). „Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade”. Proc. Natl. Acad. Sci. USA 98: 13543-13548. PMID 11698643.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.