Trans-resveratrol di-O-metiltransferaza
Trans-resveratrol di-O-metiltransferaza (EC 2.1.1.240, ROMT, resveratrolna O-metiltransferaza, pterostilbenska sintaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:trans-resveratrol 3,5-O-dimetiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Trans-resveratrol di-O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.240 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 S-adenozil-L-metionin + trans-resveratrol 2 S-adenozil-L-homocistein + pterostilben (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + trans-resveratrol S-adenozil-L-homocistein + 3-metoksi-4',5-dihidroksi-trans-stilben
- (1b) S-adenozil-L-metionin + 3-metoksi-4',5-dihidroksi-trans-stilben S-adenozil-L-homocistein + pterostilben
Ovaj enzim katalizuje biosintezu pterostilbena i resveratrola.
Reference
uredi- ↑ Schmidlin, L., Poutaraud, A., Claudel, P., Mestre, P., Prado, E., Santos-Rosa, M., Wiedemann-Merdinoglu, S., Karst, F., Merdinoglu, D. and Hugueney, P. (2008). „A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine”. Plant Physiol. 148: 1630-1639. PMID 18799660.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.