Trans-heksapreniltranstransferaza
Trans-heksapreniltranstransferaza (EC 2.5.1.30, sve-trans-heptaprenil-difosfatna sintaza, heptaprenil pirofosfatna sintaza, heptaprenil pirofosfatna sintetaza, HepPP sintaza, HepPS, heptaprenilpirofosfatna sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat farneziltranstransferaza (dodaje 4 izopentenilne jedinice).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Trans-heksapreniltranstransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.30 | ||||||||
| CAS broj | 74506-59-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (2E,6E)-farnezil difosfat + 4 izopentenil difosfat 4 difosfat + sve-trans-heptaprenil difosfat
Ovaj enzim katalizuje reakcije kondenzacije reakcije kojima se formira sve-trans-heptaprenilni difosfat, izoprenoidni bočni lanac ubihinona-7 i menahinona-7.
Reference
uredi- ↑ Takahashi, I., Ogura, K. and Seto, S. (1980). „Heptaprenyl pyrophosphate synthetase from Bacillus subtilis”. J. Biol. Chem. 255: 4539-4543. PMID 6768722.
- ↑ Zhang, Y.W., Koyama, T., Marecak, D.M., Prestwich, G.D., Maki, Y. and Ogura, K. (1998). „Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex”. Biochemistry 37: 13411-13420. PMID 9748348.
- ↑ Zhang, Y.W., Li, X.Y., Sugawara, H. and Koyama, T. (1999). „Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase”. Biochemistry 38: 14638-14643. PMID 10545188.
- ↑ Suzuki, T., Zhang, Y.W., Koyama, T., Sasaki, D.Y. and Kurihara, K. (2006). „Direct observation of substrate-enzyme complexation by surface forces measurement”. J. Am. Chem. Soc. 128: 15209-15214. PMID 17117872.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.