Trans-L-3-hidroksiprolinska dehidrataza
Trans-L-3-hidroksiprolinska dehidrataza (EC 4.2.1.77, trans-L-3-hidroksiprolinska hidrolijaza) je enzim sa sistematskim imenom trans-3-hidroksi-L-prolin hidrolijaza (formira 1-pirolidin-2-karboksilat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Trans-L-3-hidroksiprolinska dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.77 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- trans-3-hidroksi-L-prolin 1-pirolidin 2-karboksilat +H2O
Ovaj enzim je visoko specifičan.
Reference
uredi- ↑ Ramaswamy, S.G. (1983). „Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides”. Fed. Proc. 42: 2232-2232.
- ↑ Visser, W.F., Verhoeven-Duif, N.M. and de Koning, T.J. (2012). „Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes”. J. Biol. Chem. 287: 21654-21662. PMID 22528483.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.