Timin dioksigenaza
Timin dioksigenaza (EC 1.14.11.6, timinska 7-hidroksilaza, 5-hidroksi-metiluracilna dioksigenaza, 5-hidroksimetiluracilna oksigenaza) je enzim sa sistematskim imenom timin,2-oksoglutarat:kiseonik oksidoreduktaza (7-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Timin dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.6 | ||||||||
| CAS broj | 37256-67-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Za rad ovog enzima se neophodni Fe2+ i askorbat. On takođe deluje on 5-hidroksimetiluracil.
Reference
uredi- ↑ Bankel, L., Holme, E., Lindstedt, G. and Lindstedt, S. (1972). „Oxygenases involved in thymine and thymidine metabolism in Neurospora crassa”. FEBS Lett. 21: 135-138. PMID 11946494.
- ↑ Liu, C.-K., Hsu, C.-A. and Abbott, M.T. (1973). „Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase”. Arch. Biochem. Biophys. 159: 180-187. PMID 4274083.
- ↑ Warn-Cramer, B.J., Macrander, L.A. and Abbott, M.T. (1983). „Markedly different ascorbate dependencies of the sequential α-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis”. J. Biol. Chem. 258: 10551-10557. PMID 6684117.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.