Tetrahimanolna sintaza
Tetrahimanolna sintaza (EC 4.2.1.123, skvalen tetrahimanolna ciklaza) je enzim sa sistematskim imenom skvalen hidrolijaza (formira tetrahimanol).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tetrahimanolna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.123 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tetrahimanol skvalen + H2O
Ova reakcija se odvija u reverznom smeru.
Reference uredi
- ↑ Saar, J., Kader, J.C., Poralla, K. and Ourisson, G. (1991). „Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila”. Biochim. Biophys. Acta 1075: 93-101. PMID 1892870.
- ↑ Giner, J.L., Rocchetti, S., Neunlist, S., Rohmer, M. and Arigoni, D. (2005). „Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis”. Chem. Commun. (Camb.): 3089-3091. PMID 15959594.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.