Tetraacildisaharid 4'-kinaza
Tetraacildisaharid 4'-kinaza (EC 2.7.1.130, lipidna A 4'-kinaza) je enzim sa sistematskim imenom ATP:2,3,2',3'-tetrakis(3-hidroksitetradekanoil)-D-glukozaminil-beta-D-1,6-glukozaminil-beta-fosfat 4'-O-fosfotransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tetraacildisaharid 4'-kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.130 | ||||||||
| CAS broj | 107309-06-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- ATP + [2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil]-(1->6)-[2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil fosfat] ADP + [2-N,3-O-bis(3-hidroksitetradekanoil)-4-O-fosfono-beta-D-glukozaminil]-(1->6)-[2-N,3-O-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil fosfat]
Ovaj enzim učestvuje sa EC 2.3.1.129 (acil-[acil-nosilac- protein]—UDP-N-acetilglukozamin O-aciltransferazom) i EC 2.4.1.182 (lipid-A-disaharidnom sintazom) u biosintezi fosforilisanog glikolipida, lipid A, na spoljašnjoj membrani bakterije Escherichia coli.
Reference
urediLiteratura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
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