Taksadien-5a-ol O-acetiltransferaza
Taksadien-5a-ol O-acetiltransferaza (EC 2.3.1.162, acetil koenzim A:taksa-4(20),11(12)-dien-5alfa-ol O-acetil transferaza) je enzim sa sistematskim imenom acetil-KoA:taksa-4(20),11-dien-5alfa-ol O-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Taksadien-5a-ol O-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.162 | ||||||||
| CAS broj | 229032-29-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + taksa-4(20),11-dien-5alfa-ol KoA + taksa-4(20),11-dien-5alfa-il acetat
Ovo je treći enzim biosinteze diterpenoidnog antineoplastičnog leka taksola (paklitaksela).
Reference uredi
- ↑ Walker, K., Ketchum, R.E., Hezari, M., Gatfield, D., Goleniowski, M., Barthol, A. and Croteau, R. (1999). „Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis”. Arch. Biochem. Biophys. 364: 273-9. PMID 10190984.
- ↑ Walker, K., Schoendorf, A. and Croteau, R. (2000). „Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli”. Arch. Biochem. Biophys. 374: 371-380. PMID 10666320.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.