Tricetin 3',4',5'-O-trimetiltransferaza
(Preusmjereno sa stranice TaOMT2)
Tricetin 3',4',5'-O-trimetiltransferaza (EC 2.1.1.169, FOMT, TaOMT1, TaCOMT1, TaOMT2) je enzim sa sistematskim imenom S-adenozil-L-metionin:tricetin 3',4',5'-O-trimetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tricetin 3',4',5'-O-trimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.169 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3 S-adenozil-L-metionin + tricetin 3 S-adenozil-L-homocistein + 3',4',5'-O-trimetiltricetin (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + tricetin S-adenozil-L-homocistein + 3'-O-metiltricetin
- (1b) S-adenozil-L-metionin + 3'-O-metiltricetin S-adenozil-L-homocistein + 3',5'-O-dimetiltricetin
- (1c) S-adenozil-L-metionin + 3',5'-O-dimetiltricetin S-adenozil-L-homocistein + 3',4',5'-O-trimetiltricetin
Enzim iz Triticum aestivum katalizuje sekvencionu O-metilaciju tricetina putem 3'-O-metiltricetina, 3',5'-O-metiltricetina do 3',4',5'-O-trimetiltricetina.
Reference uredi
- ↑ Kornblatt, J.A., Zhou, J.M. and Ibrahim, R.K. (2008). „Structure-activity relationships of wheat flavone O-methyltransferase: a homodimer of convenience”. FEBS J. 275: 2255-2266. PMID 18397325.
- ↑ Zhou, J.M., Gold, N.D., Martin, V.J., Wollenweber, E. and Ibrahim, R.K. (2006). „Sequential O-methylation of tricetin by a single gene product in wheat”. Biochim. Biophys. Acta 1760: 1115-1124. PMID 16730127.
- ↑ Zhou, J.M., Seo, Y.W. and Ibrahim, R.K. (2009). „Biochemical characterization of a putative wheat caffeic acid O-methyltransferase”. Plant Physiol. Biochem. 47: 322-326. PMID 19211254.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.