TRNK (citozin34-C5)-metiltransferaza
TRNK (citozin34-C5)-metiltransferaza (EC 2.1.1.203, hTrm4 Mtaza, hTrm4 metiltransferaza, hTrm4 (gen), tRNK:m5C-metiltransferaza (nespecifična)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (citozin34-C5)-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK (citozin34-C5)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.203 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- S-adenozil-L-metionin + citozin34 u tRNK prekursoru S-adenozil-L-homocistein + 5-metilcitozin34 u tRNK prekursoru
Ljudski enzim je specifičan za C5-metilaciju citozina34 u tRNK prekursorima. Intron u ljudskom pre-tRNKLeu(CAA) je nezamenjiv za C5-metilaciju citozina u prvoj poziciji antikodona. Ovaj enzim ne može da formira 5-metilcitozin u pozicijama 48 i 49 ljudkih i kvašćanih tRNK prekursora.
Reference
uredi- ↑ Brzezicha, B., Schmidt, M., Makalowska, I., Jarmolowski, A., Pienkowska, J. and Szweykowska-Kulinska, Z. (2006). „Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)”. Nucleic Acids Res. 34: 6034-6043. PMID 17071714.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.