TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza
(Preusmjereno sa stranice TRNK (N2,N2-guanin)-dimetiltransferaza)
TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza (EC 2.1.1.215, Trm1, tRNK (N2,N2-guanin)-dimetiltransferaza, tRNK (m2(2)G26) metiltransferaza, Trm1(tRNK (m2(2)G26) metiltransferaza)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.215 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4 S-adenozil-L-metionin + guanin26/guanin27 u tRNK 4 S-adenozil-L-homocistein + N2-dimetilguanin26/N2-dimetilguanin27 u tRNK
Enzim iz Aquifex aeolicus je sličan sa TRM1 metiltransferazama iz arheja i eukariota (cf. EC 2.1.1.216, tRNK (guanin26-N2)-dimetiltransferaza). Međutim, on katalizuje dvostruku metilaciju guanina u pozicijama 26 i 27 tRNK.
Reference uredi
- ↑ Awai, T., Kimura, S., Tomikawa, C., Ochi, A., Ihsanawati, Bessho, Y., Yokoyama, S., Ohno, S., Nishikawa, K., Yokogawa, T., Suzuki, T. and Hori, H. (2009). „Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA”. J. Biol. Chem. 284: 20467-20478. PMID 19491098.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.