Feredoksin—NADP+ reduktaza
Feredoksin—NADP+ reduktaza (EC 1.18.1.2, feredoksin-nikotinamid adenin dinukleotid fosfatna reduktaza, feredoksin-NADP+ reduktaza, TPNH-feredoksinska reduktaza, feredoksin-NADP+ oksidoreduktaza, NADP+:feredoksin oksidoreduktaza, feredoksin-TPN reduktaza, redukovani nikotinamid adenin dinukleotid fosfat-adrenodoksinska reduktaza, feredoksin-NADP+-oksidoreduktaza, NADPH:feredoksinska oksidoreduktaza, feredoksin-nikotinamid-adenin dinukleotid fosfatna (oksidovana) reduktaza) je enzim sa sistematskim imenom feredoksin:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Feredoksin—NADP+ reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.18.1.2 | ||||||||
| CAS broj | 9029-33-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 redukovani feredoksin + NADP+ + H+ 2 oksidovani feredoksin + NADPH
Ovaj enzim je flavoprotein (FAD). U hloroplastima i cijanobakterijama ovaj enzim deluje na biljni tip [2Fe-2S] feredoksina, dok u drugim bakterijama on takođe može da zameni bakterijski [4Fe-4S] feredoksinom ili flavodoksinom.
Reference
uredi- ↑ Shin, M., Tagawa, K. and Arnon, D.I. (1963). „Crystallization of ferredoxin-TPN reductase and its role in the photosynthetic apparatus of chloroplasts”. Biochem. Z. 338: 84-96.
- ↑ Knaff, D.B. and Hirasawa, M. (1991). „Ferredoxin-dependent chloroplast enzymes”. Biochim. Biophys. Acta 1056: 93-125. PMID 1671559.
- ↑ Karplus, P.A., Daniels, M.J. and Herriott, J.R. (1991). „Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family”. Science 251: 60-66. PMID 1986412.
- ↑ Morales, R., Charon, M.H., Kachalova, G., Serre, L., Medina, M., Gomez-Moreno, C. and Frey, M. (2000). „A redox-dependent interaction between two electron-transfer partners involved in photosynthesis”. EMBO Rep. 1: 271-276. PMID 11256611.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.