Tiamin-fosfat difosforilaza
(Preusmjereno sa stranice TMP-PPase)
Tiamin-fosfat difosforilaza (EC 2.5.1.3, tiamin fosfat pirofosforilaza, tiamin monofosfat pirofosforilaza, TMP-Ppaza) je enzim sa sistematskim imenom 2-metil-4-amino-5-hidroksimetilpirimidin-difosfat:4-metil-5-(2-fosfoetil)tiazol 2-metil-4-aminopirimidin-5-meteniltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tiamin-fosfat difosforilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.3 | ||||||||
| CAS broj | 9030-30-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-metil-4-amino-5-hidroksimetilpirimidin difosfat + 4-metil-5-(2-fosfono-oksietil)tiazol difosfat + tiamin fosfat
Reference uredi
- ↑ Camiener, G.W. and Brown, G.M. (1960). „The biosynthesis of thiamine. 2. Fractionation of enzyme system and identification of thiazole monophosphate and thiamine monophosphate as intermediates”. J. Biol. Chem. 235: 2411-2417. PMID 13807175.
- ↑ Leder, I.G. (1961). „The enzymatic synthesis of thiamine monophosphate”. J. Biol. Chem. 236: 3066-3071. PMID 14463407.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.