Receptorska serin/treoninska proteinska kinaza
(Preusmjereno sa stranice TGF-beta kinase)
Serin/treonin kinaza receptorskog proteina (EC 2.7.11.30, aktivinska receptorska kinaza, receptor tip I serin/treonin proteinska kinaza, receptor tip II serin/treonin proteinska kinaza, STK13, TGF-beta kinaza, receptor serin/treonin proteinska kinaza) je enzim sa sistematskim imenom ATP:(receptor-protein) fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Serin/treonin kinaza receptorskog proteina | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.30 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Transformišući faktor rasta beta (TGF-beta) familija citokina koja reguliše ćelijsku proliferaciju, diferencijaciju, prepoznavanje i smrt. Prenos signala se odvija putem vezivanja liganda za tip II receptor, koji je konstitutivno aktivna kinaza. Vezani TGF-beta zatim prepoznaje receptor I, koji se fosforiliše i tim putem se signal dalje prenosi.
Reference
uredi- ↑ Wrana, J.L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. (1994). „Mechanism of activation of the TGF-β receptor”. Nature 370: 341-347. PMID 8047140.
- ↑ Massagué, J. and Chen, Y.G. (2000). „Controlling TGF-β signaling”. Gene 14: 627-644. PMID 10733523.
- ↑ de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B. and Lechleider, R.J. (1997). „Characterization of functional domains within Smad4/DPC4”. J. Biol. Chem. 272: 13690-13696. PMID 9153220.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.