TAS2R50
(Preusmjereno sa stranice T2R50)
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Receptor ukusa tip 2 član 50 je protein koji je kod ljudi kodiran TAS2R50 genom.[1][2][3][4]
| Receptor ukusa tip 2 član 50 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R50; T2R50; T2R51; TAS2R51 | ||||||||||
| Vanjski ID | OMIM: 609627 HomoloGene: 88474 IUPHAR: GeneCards: TAS2R50 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 259296 | n/a | |||||||||
| Ensembl | ENSG00000212126 | n/a | |||||||||
| UniProt | P59544 | n/a | |||||||||
| RefSeq (mRNA) | NM_176890.2 | n/a | |||||||||
| RefSeq (protein) | NP_795371.2 | n/a | |||||||||
| Lokacija (UCSC) | Chr 12: 11.14 - 11.14 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
TAS2R50 pripada velikoj familiji TAS2R receptora. TAS2R receptori su izraženi na površini ćelija ukusa i posreduju percepciju gorkog ukusa putem G protein spregnutog puta sekundarnih glasnika (Conte et al., 2002).[4]
Reference
uredi- ↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
- ↑ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (Feb 2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet Genome Res 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440.
- ↑ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (Sep 2005). „Identification of Four Gene Variants Associated with Myocardial Infarction”. Am J Hum Genet 77 (4): 596–605. DOI:10.1086/491674. PMC 1275608. PMID 16175505.
- ↑ 4,0 4,1 „Entrez Gene: TAS2R50 taste receptor, type 2, member 50”.
Literatura
uredi- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J i dr.. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.