1,4-Dihidroksi-2-naftoat polipreniltransferaza
(Preusmjereno sa stranice Sve-trans-poliprenil difosfat:1,4-dihidroksi-2-naftoat polipreniltransferaza)
1,4-Dihidroksi-2-naftoat polipreniltransferaza (EC 2.5.1.74, 1,4-dihydroxy-2-naphthoate polyprenyltransferase) je enzim sa sistematskim imenom sve-trans-poliprenil difosfat:1,4-dihidroksi-2-naftoat polipreniltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 1,4-Dihidroksi-2-naftoat polipreniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.74 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- sve-trans-poliprenil difosfat + 1,4-dihidroksi-2-naftoat demetilmenahinol + difosfat + CO2
Ovaj enzim katalizuje jedan od koraka sinteze menahinona.
Reference uredi
- ↑ Shineberg, B. and Young, I.G. (1976). „Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli”. Biochemistry 15: 2754-2758. PMID 949474.
- ↑ Saito, Y. and Ogura, K. (1981). „Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions”. J. Biochem. 89: 1445-1452. PMID 7275947.
- ↑ Suvarna, K., Stevenson, D., Meganathan, R. and Hudspeth, M.E. (1998). „Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli”. J. Bacteriol. 180: 2782-2787. PMID 9573170.
- ↑ Daley, D.O., Rapp, M., Granseth, E., Melen, K., Drew, D. and von Heijne, G. (2005). „Global topology analysis of the Escherichia coli inner membrane proteome”. Science 308: 1321-1323. PMID 15919996.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.